The Use of Genetic Testing for Depression which is Applied by Psychiatry-For some people, depression, and anxiety becomes a significant issue which needs immediate treatment. However, people should choose the best treatment fits them. Otherwise, it will be ineffective and brings a negative effect for a lifetime.
Therefore, some doctors and psychiatry prefer to apply a certain method namely genetic testing for depression for diagnosing the precise causes, so that it turns to the best caring and treatment for patients. The genetic testing is appropriate for patients who suffer anxiety, depression, attention deficit hyperactivity disorder (ADHD) or psychosis.
Ronald Burd, M.D., a psychiatrist of a Sanford Health, stated that genetic tests give the doctors predictions of the patient’s response to medications. It also predicts the side effects against the specific medications for certain disorders. There are two genes were tested for genetic testing for depression which results in some patterns through some steps. Here are the details.
Two Genes Classified of Genetic Testing
There are two genes tested in genetic tests which are provided for testing psychiatric disorders: Pharmacokinetics and Pharmacodynamics.
- PharmacokineticsThey relate to the way your body metabolizes the medication. Therefore, the result is used for predicting whether the patients need a low, standard, or high dose for having therapeutic effects. The genes tested here are CYP2D6, CYP2B6, CYP2C19, CYP1A2, CYP2C9, UGT1A4, CYP3A4, and UGT2B15.
This testing gene defines the kind of medication done to your body. The result of the testing shows the response of the patients whether they experience side effects of medication or not. The genes tested are SLC6A4, HTR2A, HLA-A*3101, and HLA-B*1502.
Both of those genes are important for psychiatrists to adjust the right prescriptions for a patient.
A Pattern of Genetic Testing
The genetic testing reads the patient’s genome sequence for specific patterns that are associated with the side effects or efficacy of medications. It is because genetic information codes mean what your body brings. For example, the genetic code of curly hair means you get curly hair.
The same thing happens on how the patient’s body metabolizes and responds to some medications. If the patient has the genetic code for specific parts of the serotonin reuptake pump, it indicates that the patient likely responds to an SSRI (selective serotonin reuptake inhibitor) anti-depressant.
So, when your genomic code is compared to the results of other patients, it can tell how much the dose of the medication from the doctor’s prescription. However, genetic testing is just statistical predictions and is not appropriate for all cases. The fatal side effects which are risky and make the patients hospitalized is usually decided as the time to take genetic testing.
The Steps to Get Genetic Testing
- See a specialist to take a DNA sample which is commonly done by wiping the inside of the cheek painlessly.
- The sample then is brought to the lab for analysis.
- The doctor will get the results after 36-hour-analysis.
- The doctor may use the insights from the report as a guide for the next medication selection.
Finally, genetic testing for depression is an easy way to find the appropriate medication for patients to overcome the side effects happened. It is not for diagnosing the depression, but it is for adjusting the right dose for medication.